Leyman’s Overview

Leyman’s Overview

This is a very exciting time for the research in the field of retroviruses. Even though there is a great knowledge about the mechanisms used by retroviruses to infect cells and cause diseases, we still have much more to learn. As an example, how the retrovirus traffic from the cell membrane to the nucleus is not completely clear.

Our work model, Murine Leukemia Virus (MLV), has been successfully used in the past to identified host factors that affect retroviral infection; including infection by the human immunodeficiency virus (HIV), the causative agent of one of the biggest pandemics of our time in the human population, AIDS.

The understanding of the strategies used by MLV to traffic from the cell membrane to the nucleus will provide important clues to design or develop new antiviral drugs that can specifically disrupt intracellular viral trafficking, not only of MLV but other retroviruses that affect humans and animals, such as HIV, feline immunodefiency virus (FIV) and human T-lymphotropic virus (HTLV).